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A low level of pro- apoptotic Bad or a high level of pro-survival Bcl-xL implies gate AND, which allows for the initiation of apoptosis only when two stress stimuli are simultaneously present: While IgM antibodies significantly reduced the phagocytic uptake of apoptotic thymocytes, IgG antibodies enhanced uptake.

The potential utility of this methodology for producing drugs was demonstrated in experiments in which sandalwood and Madagascar periwinkle cells were grown in an HFB. Target anticancer drugs may affect extracellular receptor domains antibodies or intracellular receptor domains tyrosine kinase inhibitors.

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In conclusion, we found that 1 cell proliferation and apoptosis are linked in retinoblastoma; 2 activation of effector caspase-3 induces apoptosis in retinoblastoma, but Bcl-2 overexpression does not prevent apoptosis in many tumors; 3 there is a pindependent pathway in approximately one-quarter of cases; 4 the findings suggesting a caspaseindependent pathway might lead to apoptosis in retinoblastoma; and, finally, we found no consistent pattern of expression of apoptotic and antiapoptotic molecules, suggesting that in retinoblastoma there is no preference for any single pathway of apoptosis.

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This paper highlights advancements in gene therapy research and its application in relation to anti-cancer treatment.

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To characterize the effect of combined pre- and postnatal morphine exposure on N-methyl-D-aspartate receptor NMDA receptor signaling in hippocampal neurons of the offspring of morphine-addicted female rats. In principle, anticancer drugs can be concentrated specifically in cancer cells and tissues by conjugating drug-containing nanocarriers with ligands against these receptors.

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Mechanistic studies aimed to provide translational evidence of effect. The consequence of the much lower toxicity of the drug, can be readily realized because cisplatin administration requires hospital stay whereas Lipoplatin can be done in an outpatient manner.

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